Prostate cancer is the second leading cause of male cancer-related death in the United States. The etiology of the prostate cancer is still unknown, and according to the 2001 study of Hsing & Devesa suggested that dietary fats, obesity, and sexual factors may be associated with increased prostate cancer risk in certain population. Increased risk to develop PCa morbidity are found to be common among a large group of men who delayed re-screening for seven or eight years. There should be continued dissemination of information regarding early screening and its association with the reduce mortality from PCa. Prostate specific antigen (PSA) concentration can predict long term risk of PCa metastasis or death.